Innovative Delivery Systems
Serostim® is administered by subcutaneous needle injection or by a needle-free delivery device that eliminates the risk of needle-stick injury.
WHAT IS SEROSTIM® [somatropin (rDNA origin) for injection]:
Serostim® is an injectable prescription medicine used for the treatment of HIV patients with wasting or cachexia to increase lean body mass and body weight, and improve physical endurance. Treatment with antiretroviral therapy at the same time is necessary.
YOU SHOULD NOT TAKE SEROSTIM® IF YOU HAVE:
A critical illness due to complications after open heart surgery, abdominal surgery, serious injuries or have severe breathing problems
Cancer or undergoing treatment for cancer
Certain types of eye diseases caused by diabetes
Allergies to growth hormone or benzyl alcohol, an ingredient in the liquid used to mix Serostim®
WHAT SHOULD I TELL MY HEALTHCARE PROVIDER BEFORE USING SEROSTIM®? Before using SEROSTIM®, tell your doctor if you have or are:
A critical illness due to complications after open heart surgery, abdominal surgery or serious injuries or have severe breathing problems
Cancer or history of cancer
Diabetes, a family history of diabetes or have been told by your doctor that you are at risk for diabetes
Multiple hormone deficiencies
Pregnant or nursing
Taking any medications, especially cyclosporine, hormone replacement therapy, insulin or other diabetes medications, drugs containing steroids, or drugs for seizures
Liver or kidney disease
Over 65 years of age
Have any other medical condition
WHAT ARE THE POSSIBLE SIDE EFFECTS OF SEROSTIM®?
SEROSTIM® MAY CAUSE SERIOUS SIDE EFFECTS INCLUDING:
Concomitant Antiretroviral Therapy:
In some experimental systems, somatropin has been shown to increase HIV replication in vitro.
Because of this possibility for acceleration of virus replication, it is recommended that you continue on your antiretroviral therapy for the duration of Serostim® treatment.
Impaired Glucose Tolerance/Diabetes:
Cases of new onset impaired glucose tolerance (pre-diabetes), new onset type 2 diabetes mellitus and worsening of current diabetes mellitus have been reported in patients receiving Serostim®. Some patients developed diabetic complications (ketoacidosis and diabetic coma). In some patients, these conditions improved when Serostim® was discontinued, while in others, the glucose intolerance persisted.
Intracranial hypertension, a rise in the pressure inside the skull, associated visual changes, headache, nausea, and/or vomiting has been reported.
Fluid Retention/Carpal Tunnel Syndrome:
Water retention may occur in adults during Serostim® therapy. Increased swelling, particularly in the hands and feet, muscle or joint pain may occur during treatment with Serostim®. Often these reactions resolve with analgesic therapy, or after decreasing the number of doses.
Carpal tunnel syndrome may occur during treatment with Serostim®. If the symptoms of carpal tunnel syndrome do not resolve by decreasing the weekly number of doses of Serostim®, it is recommended that treatment be discontinued.
Kaposi’s sarcoma, Lymphoma and other Malignancies:
Kaposi’s sarcoma (KS), lymphoma, and other malignancies are more common in HIV+ individuals. There was no increase in the incidence of Kaposi’s sarcoma, lymphoma, or in the progression of cutaneous Kaposi’s sarcoma in clinical studies of Serostim®. Patients with internal KS lesions were excluded from the studies. Potential effects on other malignancies are unknown.
Local and Systemic Reactions:
Injection sites should be changed (rotated) to avoid tissue atrophy. Patients should be informed that local and systemic reactions are possible and that prompt medical attention should be sought if allergic reactions occur.
Inflammation of the pancreas has been reported rarely in adults receiving growth hormone.
THE MOST COMMON SIDE EFFECTS OF SEROSTIM® INCLUDE:
In clinical trials the most common adverse reactions included swelling (particularly of the hands or feet), muscle pain, joint pain, numbness, and pain in extremities.
Injection site reactions (pain, numbness, redness, swelling). Change (rotate) your injection site to help lower your risk for injection site reactions.
Bone, joint or muscle pain
Swelling of the extremities Carpal tunnel syndrome
Increase in blood glucose
Increase in triglycerides
This information is not intended to replace discussion with your doctor.