Rebif® (interferon beta-1a)

Slows disability progression

Reduces relapse rates 

Reduces active brain lesions on the studied MRI measures*+

Simple starter pack with pre-measured, pre-filled doses

Rebiject II® auto-injector

3-times weekly dosing

Room temperature storage up to 30 days, if refrigeration is unavailable.

Depression. Some patients treated with interferons, including Rebif, have become seriously depressed (feeling sad). Some patients have thought about killing themselves and a few have committed suicide. Depression (a sinking of spirits or sadness) is not uncommon in people with multiple sclerosis. However, if you are feeling noticeably sadder or helpless, or feel like hurting yourself or others you should tell a family member or friend right away and call your doctor as soon as possible. Your doctor may ask that you stop using Rebif. You should also tell your doctor if you have ever had any mental illness, including depression, and if you take any medications for depression

Liver problems. Your liver may be affected by taking Rebif and a few patients have developed severe liver injury. Your health care provider may ask you to have regular blood tests to make sure that your liver is working properly. If your skin or the whites of your eyes become yellow or if you are bruising easily you should call your doctor right away 

Risk to pregnancy. If you become pregnant while taking Rebif you should stop using Rebif immediately and call your doctor. Rebif may cause you to lose your baby (miscarry) or may cause harm to your unborn child. You and your doctor will need to decide whether the potential benefit of taking Rebif is greater than the risks to your unborn child 

Allergic reactions. Some patients taking Rebif have had severe allergic reactions leading to difficulty breathing, and loss of consciousness. Allergic reactions can happen after your first dose or may not happen until after you have taken Rebif many times. Less severe allergic reactions such as itching, flushing or skin bumps can also happen at any time. If you think you are having an allergic reaction, stop using Rebif immediately and call your doctor 

Injection-site problems. Rebif may cause redness, pain or swelling at the place where an injection was given. Some patients have developed skin infections or areas of severe skin damage (necrosis) requiring treatment by a doctor. If one of your injection sites becomes swollen and painful or the area looks infected and it doesn't heal within a few days, you should call your doctor. For more information, please see medication guide

Have had an allergic reaction such as difficulty breathing, flushing or hives to another interferon beta or to human albumin

Depression (a sinking feeling or sadness), anxiety (feeling uneasy or fearful for no reason), or trouble sleeping 

Liver diseases 

Problems with your thyroid gland 

Blood problems such as bleeding or bruising easily and anemia (low red blood cells) or low white blood cells 

Epilepsy 

Are planning to become pregnant

Flu-like symptoms (fever, chills, sweating, muscle aches and tiredness) 

Skin reactions. Soreness, redness, pain, bruising or swelling may occur at the place of injection 

Depression and anxiety. Some patients taking interferons have become very depressed and or anxious 

Liver problems 

Abdominal pain 

Blood problems. You may have a drop in the levels of infection-fighting blood cells, red blood cells or cells that help to form blood clots. If the drop in levels are severe, they can lessen your ability to fight infections, make you feel tired or sluggish or cause you to bruise or bleed easily

 Thyroid problems. Your thyroid function may change. Symptoms of changes in the function of your thyroid include feeling cold or hot all the time, change in your weight (gain or loss) without a change in your diet or amount of exercise you are getting 

Severe allergic reactions. Allergic reactions are rare and may be associated with difficulty in breathing and loss of consciousness, which require immediate medical attention