Transforming Cancer Care Today and Tomorrow
Incredible progress has been made in the field of oncology to help improve the lives of many people affected by cancer. Yet that work is far from done. We believe that much more can and must be done to transform cancer care and patient outcomes.
We are a science-led organization of curious minds dedicated to delivering transformative cancer medicines to the people who need them. Curiosity drives us to discover and develop medicines for several challenging cancers, and patients inspire us to relentlessly pursue scientific breakthroughs that will help make a difference in their lives.
INSPIRED TO IMPROVE STANDARDS OF CARE FOR CHALLENGING CANCERS
We are leveraging our synergistic portfolio in oncogenic pathways, immuno-oncology, and DNA Damage Response (DDR), and focusing our scientific discovery and development with our goal to unleash the potential of several promising approaches in cancer research.
Our Tumor Focus
BILIARY TRACT CANCERS
Biliary tract cancer forms in the cells of the bile ducts, gallbladder or ampulla of Vater.1 Each year, an estimated 8,000 people in the United States are diagnosed with bile duct cancer.2
GYNECOLOGIC AND HPV-RELATED CANCERS
Gynecologic cancers are cancers that start in the female reproductive organs, including cervical, uterine, ovarian, vaginal, and vulvar cancer.3 Human Papillomavirus (HPV) is associated with nearly 90% of cervical cancer and about 70% of vaginal and vulvar cancers.4
HEAD AND NECK CANCER
Squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide. Approximately 600,000 new cases are diagnosed each year, including about 50,000 in the United States.5
Non-small cell lung cancer is considered the most common type of lung cancer, accounting for 85% of all cases,6 while small cell lung cancer makes up approximately 15%.7 In the US there are more than 230,000 new cases of lung cancer and 130,000 deaths each year.8
MERKEL CELL CARCINOMA
Merkel cell carcinoma is a rare and aggressive form of skin cancer impacting approximately 2,000 people in the United States every year.9
RENAL CELL CARCINOMA
Renal cell carcinoma is the most common type of kidney cancer, accounting for approximately 85% of all malignant kidney tumors.10
Urothelial carcinoma is a cancer that starts in the urothelial cells that line the inside of the bladder.11 It’s the 6th most common cancer in the United States – with more than 80,000 new cases estimated in 2021.12
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1 American Cancer Society. What Is Bile Duct Cancer? Available at: https://www.cancer.org/cancer/bile-duct-cancer/about/what-is-bile-duct-cancer.html. Accessed May 3, 2021.
2 American Cancer Society. Key Statistics for Bile Duct Cancer. Available at: https://www.cancer.org/cancer/bile-duct-cancer/about/key-statistics.html. Accessed May 3, 2021.
3 Centers for Disease Control and Prevention. Basic Information About Gynecologic Cancers. Available at: https://www.cdc.gov/cancer/gynecologic/basic_info/index.htm. Accessed May 3, 2021.
4 Centers for Disease Control and Prevention. Cancers Associated with Human Papillomavirus (HPV). Available at: https://www.cdc.gov/cancer/hpv/basic_info/cancers.htm. Accessed May 3, 2021.
5 Rothenberg, S. M., & Ellisen, L. W. The molecular pathogenesis of head and neck squamous cell carcinoma. The Journal of clinical investigation, 122(6), 1951–1957.
6 American Cancer Society. What Is Lung Cancer? Available at: https://www.cancer.org/cancer/lung-cancer/about/what-is.html. Accessed May 3, 2021.
7 Wang S, et al. Sci Rep. 2017;(1):1339.
8 American Cancer Society. Key Statistics for Lung Cancer. Available at: https://www.cancer.org/cancer/lung-cancer/about/key-statistics.html. Accessed May 3, 2021.
9 American Cancer Society. Key Statistics for Merkel Cell Carcinoma. Available at: https://www.cancer.org/cancer/merkel-cell-skin-cancer/about/key-statistics.html. Accessed May 3, 2021.
10 Cleveland Clinic. Kidney Cancer. Available at: https://my.clevelandclinic.org/health/diseases/9409-kidney-cancer-overview. Accessed May 3, 2021.
11 Cancer.net. Bladder Cancer: Introduction. https://www.cancer.net/cancer-types/bladder-cancer/introduction. Accessed May 4, 2021.
12 National Cancer Institute. Cancer Stat Facts: Bladder Cancer. Available at: https://seer.cancer.gov/statfacts/html/urinb.html. Accessed May 4, 2021.